Bioactive compounds of Allium sativum (Garlic) & their pharmacological properties

Alok Tripathi1, Surabhi Singhal1, Navneet Sharma1

1. School of Life Science & Technology, IIMT University, Meerut, U.P., India


Allium sativum (Garlic) is considered as most significant herbs that have been used as traditional medicine from very old times. From ancient to current time different studies have confirmed the significant biological activities of garlic which includes anti-infectious properties, anti-inflammatory, antioxidant, anti-obesity, cardiovascular protective, anti-diabetic, free radical scavenging and anticancer properties.

Allium sativum has a diverse range of bioactive compounds and these are mainly organosulfur compounds, phenolic compounds and saponins. Primarily dominating phytochemicals are sulfur-containing compounds which are Alliin (C6H11NO3S), Allicin (C6H10OS2), E-Ajoene (C9H14OS3), Z-Ajoene (C9H14OS3), 2-Vinyl-4H-1,3-dithiin (C6H8S2), Diallyl sulfide (C6H10S), Diallyl disulfide (C6H10S2), Diallyl trisulfide (C6H10S3), Allyl methyl sulfide (C4H8S). It’s found that bioavailability of capsule prepared by garlic powder is in the range of 26-109 % while bioavailability of non enteric tablets is in the range of 80-111 %. It shows that bioavailability of tablets are more in comparison to capsule of garlic powder

Current review discusses the chemical bioactive compound compositions of the Allium sativum (Garlic) and its pharmacological properties, which prove the importance of garlic in the cure of different types of diseases.

Keywords: Garlic, Allium Sativum, Antioxidant, Anti-inflammatory, Anticancer

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Article ID: P0301014    RA
Received: 03/03/2021  
Accepted: 14/04/2021
Published: 30/09/2021

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